Prognostic and Predictive Markers in Metastatic Renal Cell Carcinoma

Khattak, Muhammad A. ; Bakr, Farrah ; Krzystanek, Marcin ; Szallasi, Zoltan Imre ; Gerlinger, Marco ; Santos, Claudio ; Swanton, Charles ; Pickering, Lisa M. ; Gore, Martin E. ; Larkin, James M.G.

in journal: Journal of Clinical Oncology (ISSN: 0732-183X) (DOI: http://dx.doi.org/10.1200/JCO.2012.46.9353), vol: 31, issue: 7, pages: 20971-972, 2013

Type: Journal article - Journal article

DOI: 10.1200/JCO.2012.46.9353

45p deciphering patterns of chromosomal aberrations in breast cancer patients: how defects in specific dna repair genes affect the accumulation of gross dna aberrations in the cancer genome

Marquard, Andrea Marion ; Birkbak, Nicolai Juul ; Eklund, Aron Charles ; Varga, A. ; Szüts, D. ; Szallasi, Zoltan Imre

in journal: Annals of Oncology (ISSN: 0923-7534) (DOI: http://dx.doi.org/10.1093/annonc/mdt083.6), vol: 24, issue: suppl 3, pages: iii26, 2013

Type: Journal article - Journal article

DOI: 10.1093/annonc/mdt083.6

31P gain of chromosomal region 15q26 cause increased expression of blm and fanci, and is associated with sensitivity to platinum chemotherapy in triple negative breast cancer

Birkbak, Nicolai Juul ; Li, Y. ; Bowman-Collin, C. ; Iglehart, J.D. ; Silver, D. ; Wang, Z.C. ; Szallasi, Zoltan Imre ; Richardson, A.

in journal: Annals of Oncology (ISSN: 0923-7534) (DOI: http://dx.doi.org/10.1093/annonc/mdt082.3), vol: 24, issue: suppl 3, pages: iii22, 2013

Type: Journal article - Journal article

DOI: 10.1093/annonc/mdt082.3

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

Győrffy, Balázs ; Lánczky, András ; Szallasi, Zoltan Imre

in journal: Endocrine - Related Cancer (ISSN: 1351-0088) (DOI: http://dx.doi.org/10.1530/ERC-11-0329), vol: 19, issue: 2, pages: 197-208, 2012

Type: Journal article - Journal article

DOI: 10.1530/ERC-11-0329

Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents

Birkbak, Nicolai Juul ; Wang, Zhigang C. ; Kim, Ji-Young ; Eklund, Aron Charles ; Li, Qiyuan ; Tian, Ruiyang ; Bowman-Colin, Christian ; Li, Yang ; Greene-Colozzi, April ; Iglehart, J. Dirk ; Tung, Nadine ; Ryan, Paula D. ; Garber, Judy E. ; Silver, Daniel P. ; Szallasi, Zoltan Imre ; Richardson, Andrea L.

in journal: Cancer Drug Discovery and Development (DOI: http://dx.doi.org/10.1158/2159-8290.CD-11-0206), vol: 2, issue: 4, pages: 366-375, 2012

Type: Journal article - Journal article

DOI: 10.1158/2159-8290.CD-11-0206

Parallel Evolution under Chemotherapy Pressure in 29 Breast Cancer Cell Lines Results in Dissimilar Mechanisms of Resistance

Tegze, Balint ; Szallasi, Zoltan Imre ; Haltrich, Iren ; Penzvalto, Zsofia ; Toth, Zsuzsa ; Liko, Istvan ; Gyoerffy, Balazs

in journal: P L o S One (ISSN: 1932-6203) (DOI: http://dx.doi.org/10.1371/journal.pone.0030804), vol: 7, issue: 2, pages: e30804, 2012

Type: Journal article - Journal article

DOI: 10.1371/journal.pone.0030804

Methods for predicting anti-cancer response

Szallasi, Zoltan Imre ; Eklund, Aron Charles ; Birkbak, Nicolai Juul ; Richardson, Andrea L. ; Silver, Daniel P. ; Wang, Zhigang

Type: Patent - Patent

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, Marco ; Rowan, Andrew J. ; Horswell, Stuart ; Larkin, James ; Endesfelder, David ; Gronroos, Eva ; Martinez, Pierre ; Matthews, Nicholas ; Stewart, Aengus ; Tarpey, Patrick ; Varela, Ignacio ; Phillimore, Benjamin ; Begum, Sharmin ; McDonald, Neil Q. ; Butler, Adam ; Jones, David ; Raine, Keiran ; Latimer, Calli ; Santos, Claudio R. ; Nohadani, Mahrokh ; Eklund, Aron Charles ; Spencer-Dene, Bradley ; Clark, Graham ; Pickering, Lisa ; Stamp, Gordon ; Gore, Martin ; Szallasi, Zoltan Imre ; Downward, Julian ; Futreal, P. Andrew ; Swanton, Charles

in journal: New England Journal of Medicine (ISSN: 0028-4793), vol: 366, issue: 10, pages: 883-892, 2012

Type: Journal article - Journal article

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction

Lee, Alvin J. X. ; Roylance, Rebecca ; Sander, Jil ; Gorman, Patricia ; Endesfelder, David ; Kschischo, Maik ; Jones, Neil P. ; East, Philip ; Nicke, Barbara ; Spassieva, Stefka ; Obeid, Lina M. ; Birkbak, Nicolai Juul ; Szallasi, Zoltan Imre ; McKnight, Nicole C. ; Rowan, Andrew J. ; Speirs, Valerie ; Hanby, Andrew M. ; Downward, Julian ; Tooze, Sharon A. ; Swanton, Charles

in journal: Journal of Pathology (ISSN: 0022-3417) (DOI: http://dx.doi.org/10.1002/path.2998), vol: 226, issue: 3, pages: 482-494, 2012

Type: Journal article - Journal article

DOI: 10.1002/path.2998

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

Birkbak, Nicolai Juul ; Eklund, Aron Charles ; Li, Qiyuan ; McClelland, Sarah E. ; Endesfelder, David ; Tan, Patrick ; Tan, Iain B. ; Richardson, Andrea L. ; Szallasi, Zoltan Imre ; Swanton, Charles

in journal: Cancer Research (ISSN: 0008-5472) (DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-3667), vol: 71, issue: 10, pages: 3447-3452, 2011

Type: Journal article - Journal article

DOI: 10.1158/0008-5472.CAN-10-3667

Chromosomal Instability Confers Intrinsic Multidrug Resistance

Lee, Alvin J. X. ; Endesfelder, David ; Rowan, Andrew J. ; Walther, Axel ; Birkbak, Nicolai Juul ; Futreal, P. Andrew ; Downward, Julian ; Szallasi, Zoltan Imre ; Tomlinson, Ian P. M. ; Howell, Michael ; Kschischo, Maik ; Swanton, Charles

in journal: Cancer Research (ISSN: 0008-5472) (DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-3604), vol: 71, issue: 5, pages: 1858-1870, 2011

Type: Journal article - Journal article

DOI: 10.1158/0008-5472.CAN-10-3604

Parallel selection of chemotherapy-resistant cell lines to illuminate mechanisms of drug resistance in human tumors

Krzystanek, Marcin ; Eklund, Aron Charles ; Birkbak, Nicolai Juul ; Tegze, B. ; Gautier, Laurent ; Holberg Blicher, Lene ; Swanton, C. ; Richardson, A. L. ; Gyorffy, B. ; Szallasi, Zoltan Imre

in journal: ANNALS OF ONCOLOGY (ISSN: 0923-7534) (DOI: http://dx.doi.org/10.1093/annonc/mdr086), vol: 22, issue: 2, pages: ii44-ii47, 2011

Type: Conference article - Conference article

Presented at: Conference on Improving Care and Knowledge through Translational Research : Breast Cancer Conference, Brussels, Belgium

DOI: 10.1093/annonc/mdr086

Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response

Li, Qiyuan ; Eklund, Aron Charles ; Birkbak, Nicolai Juul ; Desmedt, Christine ; Haibe-Kains, Benjamin ; Sotiriou, Christos ; Symmans, W. Fraser ; Pusztai, Lajos ; Brunak, Søren ; Richardson, Andrea L ; Szallasi, Zoltan Imre

in journal: B M C Bioinformatics (ISSN: 1471-2105) (DOI: http://dx.doi.org/10.1186/1471-2105-12-310), vol: 12, issue: 1, pages: 310, 2011

Type: Journal article - Journal article

DOI: 10.1186/1471-2105-12-310

Jetset: selecting the optimal microarray probe set to represent a gene

Li, Qiyuan ; Birkbak, Nicolai Juul ; Gyorffy, Balazs ; Szallasi, Zoltan Imre ; Eklund, Aron Charles

in journal: B M C Bioinformatics (ISSN: 1471-2105) (DOI: http://dx.doi.org/10.1186/1471-2105-12-474), vol: 12, issue: 1, pages: 474, 2011

Type: Journal article - Journal article

DOI: 10.1186/1471-2105-12-474

Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer

Roylance, Rebecca ; Endesfelder, David ; Gorman, Patricia ; Sander, Jil ; Tomlinson, Ian ; M. Hanby, Andrew ; Speirs, Valerie ; L. Richardson, Andrea ; Birkbak, Nicolai Juul ; Eklund, Aron Charles ; Downward, Julian ; Kschischo, Maik ; Szallasi, Zoltan Imre ; Swanton, Charles

in journal: Cancer Epidemiology, Biomarkers & Prevention (ISSN: 1055-9965) (DOI: http://dx.doi.org/10.1158/1055-9965.EPI-11-0343), pages: 2184-2197, 2011

Type: Journal article - Journal article

DOI: 10.1158/1055-9965.EPI-11-0343

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.

Endesfelder, David ; McGranahan, Nicholas ; Birkbak, Nicolai Juul ; Szallasi, Zoltan Imre ; Kschischo, Maik ; A. Graham, Trevor ; Swanton, Charles

in journal: OncoTarget (ISSN: 1949-2553), 2011

Type: Journal article - Journal article

Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

Birkbak, Nicolai Juul ; Szallasi, Zoltan Imre ; Eklund, Aron Charles ; Li, Qiyuan ; Burrell, RA ; Gerlinger, M ; Valero, V ; Andreopoulou, E ; Esteva, FJ ; Symmans, WF ; Desmedt, C ; Haibe-Kains, B ; Sotiriou, C ; Pusztai, L ; Swanton, C

in journal: Lancet Oncology (ISSN: 1470-2045) (DOI: http://dx.doi.org/10.1016/S1470-2045(10)70018-8), vol: 11, issue: 4, pages: 358-365, 2010

Type: Journal article - Journal article

DOI: 10.1016/S1470-2045(10)70018-8

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

Szallasi, Zoltan Imre ; Eklund, Aron Charles ; Li, Qiyuan ; Birkbak, Nicolai Juul ; Silver, Daniel P. ; Richardson, Andrea L. ; Wang, Zhigang C. ; Leong, Chee-Onn ; Calogrias, Diana ; Buraimoh, Ayodele ; Fatima, Aquila ; Gelman, Rebecca S. ; Ryan, Paula D. ; Tung, Nadine M. ; De Nicolo, Arcangela ; Ganesan, Shridar ; Miron, Alexander ; Colin, Christian ; Sgroi, Dennis C. ; Ellisen, Leif W. ; Winer, Eric P. ; Garber, Judy E.

in journal: Journal of Clinical Oncology (ISSN: 0732-183X) (DOI: http://dx.doi.org/10.1200/JCO.2009.22.4725), vol: 28, issue: 7, pages: 1145-1153, 2010

Type: Journal article - Journal article

DOI: 10.1200/JCO.2009.22.4725

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

Szallasi, Zoltan Imre ; Li, Yang ; Zou, Lihua ; Li, Qiyuan ; Haibe-Kains, Benjamin ; Tian, Ruiyang ; Li, Yan ; Desmedt, Christine ; Sotiriou, Christos ; Iglehart, J Dirk ; Richardson, Andrea L ; Wang, Zhigang Charles

in journal: Nature Medicine (ISSN: 1078-8956) (DOI: http://dx.doi.org/10.1038/nm.2090), vol: 16, issue: 2, pages: 214-218, 2010

Type: Journal article - Journal article

DOI: 10.1038/nm.2090

Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

Swanton, C. ; Larkin, J.M. ; Gerlinger, M. ; Eklund, Aron Charles ; Howell, M. ; Stamp, G. ; Downward, J. ; Gore, M. ; Futreal, P.A. ; Escudier, B. ; Andre, F. ; Albiges, L. ; Beuselinck, B. ; Oudard, S. ; Hoffmann, J. ; Gyorffy, B. ; Torrance, C. ; Boehme, K.A. ; Volkmer, H. ; Toschi, L. ; Nicke, B. ; Beck, Marlene ; Szallasi, Zoltan Imre

in journal: Genome Medicine (ISSN: 1756-994X) (DOI: http://dx.doi.org/10.1186/gm174), vol: 2, issue: 8, 2010

Type: Journal article - Journal article

DOI: 10.1186/gm174