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Title: Production of fumonisins B2 and B4 in Tolypocladium species
Type: Journal articleJournal article
Participant(s):
Author:  Mogensen, Jesper Mølgaard (Cwisno: 15987)
Technical University of Denmark
Email:

Author:  Møller, Kirsten Amalie (Cwisno: 42796)
Technical University of Denmark
Email:

Forfatter:  von Freiesleben, Pernille
Technical University of Denmark

Forfatter:  Labuda, Roman
Romer Labs Division Holding GmbH

Forfatter:  Varga, Elisabeth
University of Natural Resources and Applied Life Sciences, Department IFA-Tulln

Forfatter:  Sulyok, Michael
University of Natural Resources and Applied Life Sciences, Department IFA-Tulln

Forfatter:  Kubátová, Alena
Charles University in Prague, Department of Botany

Author:  Thrane, Ulf (Cwisno: 2487)
Technical University of Denmark
Email:

Author:  Andersen, Birgitte (Cwisno: 37)
Technical University of Denmark
Email:

Author:  Nielsen, Kristian Fog (Cwisno: 4094)
Technical University of Denmark
Email:

Abstract: Tolypocladium inflatum is known primarily for its production of the cyclosporines that are used as an immunosuppressive drug. However, we report here the production of the carcinogenic fumonisins B2 and B4 by this biotechnologically relevant fungal genus. These mycotoxins were detected in 11 strains tested from three species: Tolypocladium inflatum, T. cylindrosporum, and T. geodes. Production of fumonisins by Fusarium spp. and Aspergillus niger is highly medium- and temperature-dependent, so the effect of these parameters on fumonisin production by three T. inflatum strains was studied. Maximum production was achieved on media with high sugar content incubated at 25–30°C. Since these results demonstrate that fumonisin production could be widespread within the genus Tolypocladium, the potential contamination of commercial cyclosporine preparations with fumonisins needs to be investigated.
Published: in journal: Journal of Industrial Microbiology and Biotechnology (ISSN: 1367-5435) (DOI: http://dx.doi.org/10.1007/s10295-010-0916-1), vol: 38, issue: 9, pages: 1329-1335, 2011
DOI:
See the publication in DTU Orbit See the publication in DTU Orbit

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